SOPHAS – Automated High Throughput Synthesis Workstation
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SOPHAS represents a new generation of automatic modular solid phase synthesisers capable of many hundred syntheses in a single run. It comprises of an automatic workbench with liquid handling tools and an integrated robotic handler, which provides maximum freedom in the choice of reactors ranging from 96 well plates to 25 ml reaction vessels. This enables the use of various strategies and chemistries for organic synthesis. The synthesis can be carried out in any kind of reaction vessel, such as 96 well plates, tubes or vials, made of any suitable material i.e. glass, plastic, ceramics, stainless steel, titanium. These vessels are placed on aluminium carriers and transported by the integrated robotic arm to the various stations, heating, cooling, washing or parking on the workbench. SOPHAS provides fast heating and cooling between -40°C (-80°C optional) and +150°C along with mechanical agitation by newly developed high-speed, low noise vortexers at any stage of the synthesis and at any position of the workbench. Speeds and temperatures can be set individually and are software controlled. As an option, pick-up tools can be supplied with sensors for level detection, temperature measurement and pH control to monitor the chemical reactions. SOPHAS can be customised to comprise of liquid handling, heating, cooling and mixing functions with many optional tools such as powder handling, weighing, microwave-assisted synthesis, sonication and pH measurement & adjustment. |
