CALLI – Automated Powder Handling for Library Compounds
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Compound libraries are the heart of every pharmaceutical company. Liquid handling for the dissolution of the library compounds has been automated for many years. The most tedious procedure is the distribution and weighing of the original solid dry-stored library compound, which is still done manually. The CALLI fills this gap. It is specifically designed for the distribution of dry, powder library samples for dissolution, distributing the samples directly from their original library vial without any additional preparation step.CALLI is an automatic platform with a robotic arm supplied with a powder dispensing probe and a handler for transportation of vials. The distribution process is controlled by a built in weighing cell to monitor the mass distribution of powders in the range from less than 1mg to 50mg. A Typical Workflow The new system detects the level of the solid material in the original library vial. Even a small layer on the bottom can be transferred to the dissolution vial or plate. The unique software algorithm chooses the most suitable technique for aspiration of the powder, and in combination with the balance allows target weighing with a high degree of precision. The final target weight is monitored by the balance and documented together with the container data (number, position on the container, time of distribution etc.) in the database. The CALLI can also be customised to include vortexers, sonicators, stirrers or visual control of the samples to automate the entire workflow. |
MOSS 2002 - Automated Test Plate & Assay Plate Preparation
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The MOSS 2002 is a modular sample preparation system that prepares samples from compound libraries for high throughput screening. The database software controls the weighing, dissolution and sample distribution. It keeps track of the samples and exchanges data with all commercial mass storage databases such as ORACLE.
The MOSS 2002 is extremely fast due to 8 independently spaced tips with high speed movement in the X, Y & Z axes. It combines modern weighing technology and sophisticated software to automate library sample weighing & dissolution with assay and storage plate preparation. As the presence of water in DMSO will drastically the compound solubility, the entire dissolution step is performed under argon. With its enhanced technology it is not necessary to flood the entire system with argon, thus keeping the cost and weight of the instrument to a minimum. Tilting dissolution vials offer complete retrieval of sample material. The compact design, high throughput, reliability and easy integration into existing infrastructures have made the MOSS 2002 the system of choice for high throughput testing labs. |
